Nanosizing a Metal–Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis
نویسندگان
چکیده
منابع مشابه
Nanosizing a Metal-Organic Framework Enzyme Carrier for Accelerating Nerve Agent Hydrolysis.
We report the synthesis and characterization of a water-stable zirconium metal-organic framework (MOF), NU-1003, featuring the largest mesoporous aperture known for a zirconium MOF. This material has been used to immobilize the nerve agent hydrolyzing enzyme, organophosphorus acid anhydrolase (OPAA). The catalytic efficiency of immobilized OPAA in nanosized NU-1003 is significantly increased co...
متن کاملNerve Agent Hydrolysis Activity Designed into a Human Drug Metabolism Enzyme
Organophosphorus (OP) nerve agents are potent suicide inhibitors of the essential neurotransmitter-regulating enzyme acetylcholinesterase. Due to their acute toxicity, there is significant interest in developing effective countermeasures to OP poisoning. Here we impart nerve agent hydrolysis activity into the human drug metabolism enzyme carboxylesterase 1. Using crystal structures of the targe...
متن کاملInstantaneous hydrolysis of nerve-agent simulants with a six-connected zirconium-based metal-organic framework.
A nerve-agent simulant based on a phosphate ester is hydrolyzed using a MOF-based catalyst. Suspensions of MOF-808 (6-connected), a material featuring 6-connected zirconium nodes, display the highest hydrolysis rates among all MOFs that have been reported to date. A plug-flow reactor was also prepared with MOF-808 (6-connected) as the active layer. Deployed in a simple filtration scheme, the re...
متن کاملNanometric MIL-125-NH2 Metal–Organic Framework as a Potential Nerve Agent Antidote Carrier
The three-dimensional (3D) microporous titanium aminoterephthalate MIL-125-NH₂ (MIL: Material of Institut Lavoisier) was successfully isolated as monodispersed nanoparticles, which are compatible with intravenous administration, by using a simple, safe and low-cost synthetic approach (100 °C/32 h under atmospheric pressure) so that for the first time it could be considered for encapsulation and...
متن کاملA Framework for Accelerating High - dimensionalNN
The performance of nearest neighbor (NN) queries degrades noticeably with increasing di-mensionality of the data. This stems not only from reduced selectivity of high-dimensional data but also from an increased number of seek operations during query execution. We propose a new framework to transform NN queries into at most two range queries. This is achieved by rst estimating the NN-radius, per...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Nano
سال: 2016
ISSN: 1936-0851,1936-086X
DOI: 10.1021/acsnano.6b04996